Press releases

Pharmacy

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New project to improve drugs safety in East Africa

4 September, 2018 - Karolinska Institutet

In recent years access to drugs and vaccines has been increasing in many African countries, but the systems for monitoring treatment effects and reporting side-effects require further development. Karolinska Institutet in Sweden will now lead an international collaboration project on pharmacovigilance – drugs safety – in four countries in East Africa.

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New method reduces adverse effects of rectal cancer treatment

10 February, 2017 - Karolinska Institutet

A new study from Karolinska Institutet shows that short-course preoperative radiotherapy combined with delayed surgery reduces the adverse side-effects of rectal cancer surgery without compromising its efficacy. The results are presented in the journal The Lancet Oncology.

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Upsalite® inhibit bacteria without penicillin

16 November, 2016 - Uppsala universitet

The mesoporous magnesium carbonate Upsalite® is shown to inhibit growth of Staphylococcus epidermidis, bacteria associated with acne and hospital acquired infections. That is the result of a study published in ACS Omega, by researchers at Uppsala University. The results open up for development of materials inhibiting bacterial growth without the use of antibiotics for e.g. dermal applications.

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Chameleonic properties make large molecules into possible drugs

17 October, 2016 - Uppsala universitet

In a paper published today in Nature Chemical Biology, a team of researchers from Uppsala University, the Broad Institute of MIT, Harvard, and AstraZeneca are presenting new insights into how larger-than-average molecules can be developed into pharmaceutical drugs

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New principle for brain-controlled hormone secretion

15 April, 2016 - Karolinska Institutet

The concentration of the hormone prolactin in the blood is controlled by dopamine. However, the system can be thrown off balance by certain drugs, especially antipsychotics, which can result in sexual side effects. A new study from Karolinska Institutet in rats, published in the journal Cell Reports, shows how dopamine can regulate itself and provides new knowledge about how the side effects arise.

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Early HPV vaccination provides best protection

9 March, 2016 - Karolinska Institutet

The HPV vaccine is most effective against high-grade cervical lesions if given before the age of 17, according to a new register-based study from Karolinska Institutet and the Public Health Agency of Sweden. The results, which are published in the International Journal of Cancer, show that the vaccine is effective at preventing high-grade lesions.

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Type 2 diabetes drug can exhaust insulin-producing cells

12 February, 2016 - Karolinska Institutet

Long-term use of liraglutide, a substance that helps to lower blood sugar levels in patients with type 2 diabetes, can have a deteriorating effect on insulin-producing beta cells, leading to an increase in blood sugar levels. This according to a study on mice implanted with human insulin-producing cells conducted by a team of scientists from Karolinska Institutet, and the University of Miami, USA.

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A step closer to understanding fertilisation

9 February, 2016 - Karolinska Institutet

Researchers at Karolinska Institutet have taken a step closer to understanding the mechanism that leads to the fusion of egg and sperm at fertilisation. Using the technique X-ray crystallography, they have determined the 3D structure of Juno, a mammalian egg protein essential for triggering gamete fusion. Their findings are not only interesting from an evolutionary perspective, but also reveal the shape of a possible target for future non-hormonal contraceptives.

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Mosquito net safe to use in inguinal hernia repair

14 January, 2016 - Karolinska Institutet

Sterilised mosquito nets can replace costly surgical meshes in the repair of inguinal (groin) hernias without further risk to the patients. This makes mosquito nets a good alternative for close to 200 million people in low-income countries suffering from untreated groin hernias. These are the results of a Swedish-Ugandan study presented in the prestigious New England Journal of Medicine (NEJM).