Press releases

Pharmacy

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New biomarker may uncover uncontrolled asthma  

20 August, 2019 - Karolinska Institutet

Cytokines are a type of proteins that are important to the signaling between cells in the body’s immune system, for example in the case of an infection or injury. A new study which is being published in the Journal of Allergy and Clinical Immunology is now indicating that the cytokine interleukin(IL)-26 could be used as a biological marker (biomarker) for uncontrolled asthma in both adults and children – and could perhaps also be a future goal for new drugs against asthma. These results are presented by researchers at Karolinska Institutet and Lund University.

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Statins can prevent liver cancer

20 August, 2019 - Karolinska Institutet

Fat-soluble statins can prevent liver cancer and reduce mortality in patients with chronic viral hepatitis. These are findings from a study conducted by researchers at Karolinska Institutet in Sweden, among others. The study is published in Annals of Internal Medicine.

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Novel findings explain indirect regulation of glucose homeostasis

16 August, 2019 - Karolinska Institutet

The hormone secreting part of the pancreas, the islets of Langerhans, has a unique cyto-architecture that allows functional interrelationships between the different cell types. Somatostatin is secreted by the delta cell and is an effective inhibitor of the insulin secreting beta cell and the glucagon secreting alpha cell. According to a novel study from Sweden’s Karolinska Instiutet, published in the journal Nature Communications, the delta cell can thereby indirectly affect glucose homeostasis in health and disease.

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Hormonal therapy has a long-term effect in breast cancer

8 August, 2019 - Karolinska Institutet

Researchers at Karolinska Institutet in Sweden have investigated the long-term effect of hormonal therapy in women with the most common types of hormone-sensitive breast cancer. The results, presented in the journal JAMA Oncology, show that the treatment has a protective effect against distant metastatic cancer for both so-called Luminal A and Luminal B breast cancer subtypes, and a long-term effect for women diagnosed with Luminal A cancer.

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New project to improve drugs safety in East Africa

4 September, 2018 - Karolinska Institutet

In recent years access to drugs and vaccines has been increasing in many African countries, but the systems for monitoring treatment effects and reporting side-effects require further development. Karolinska Institutet in Sweden will now lead an international collaboration project on pharmacovigilance – drugs safety – in four countries in East Africa.

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New method reduces adverse effects of rectal cancer treatment

10 February, 2017 - Karolinska Institutet

A new study from Karolinska Institutet shows that short-course preoperative radiotherapy combined with delayed surgery reduces the adverse side-effects of rectal cancer surgery without compromising its efficacy. The results are presented in the journal The Lancet Oncology.

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Upsalite® inhibit bacteria without penicillin

16 November, 2016 - Uppsala universitet

The mesoporous magnesium carbonate Upsalite® is shown to inhibit growth of Staphylococcus epidermidis, bacteria associated with acne and hospital acquired infections. That is the result of a study published in ACS Omega, by researchers at Uppsala University. The results open up for development of materials inhibiting bacterial growth without the use of antibiotics for e.g. dermal applications.

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Chameleonic properties make large molecules into possible drugs

17 October, 2016 - Uppsala universitet

In a paper published today in Nature Chemical Biology, a team of researchers from Uppsala University, the Broad Institute of MIT, Harvard, and AstraZeneca are presenting new insights into how larger-than-average molecules can be developed into pharmaceutical drugs

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New principle for brain-controlled hormone secretion

15 April, 2016 - Karolinska Institutet

The concentration of the hormone prolactin in the blood is controlled by dopamine. However, the system can be thrown off balance by certain drugs, especially antipsychotics, which can result in sexual side effects. A new study from Karolinska Institutet in rats, published in the journal Cell Reports, shows how dopamine can regulate itself and provides new knowledge about how the side effects arise.